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KMID : 0861020090240040159
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Korea Journal of Herbology
2009 Volume.24 No. 4 p.159 ~ p.164
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Antioxidant Activities and the Effect of Reducing Serum Alcohol Concentration of Lentinus edodes
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Kim Chae-Hyun
Jeong Jong-Gil
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Abstract
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Objectives: The purpose of this study is to evaluate antioxidant activities and reducing serum alchol concentration of extract of Lentinus edodes on the alcohol administered rats.
Methods: Antioxidant effect was measured by total phenolic compound and DPPH-radical scavenging activity of extract of Lentinus edodes in vitro. Blood alcohol concentration, aldehyde concentration, malondialdehyde concentration, glutathion concentration were measured in vivo.
Results: The extract of Lentinus edodes increased DPPH-radical scavenging activity dose-dependently. The water extract with boiling water showed lower antioxidant activity and phenolic content than 70% ethanol extract in vitro. Blood alcohol concentration was significantly reduced by pre-treatment of ethanol extract of Lentinus edodes. The effect was more significant than commercial product used as a positive control.
Conclusions: This study suggest that Lentinus edodes can be a potential nature resource for the management of ethanol toxicity although the mechanism of action involved in the treatment remains to be explored.
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KEYWORD
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Lentinus edodes, serum alcohol concentration, ethanol toxicity, antioxidant activity
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